Ali Sadra;Minmin Qin;Ernestine Lee;Elizabeth Bosch;Diane Hollenbaugh
发明人:
Elizabeth Bosch,Diane Hollenbaugh,Ernestine Lee,Minmin Qin,Ali Sadra
申请号：
US13157712
公开号：
US08173134B2
申请日:
2011.06.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein.
