PURPOSE: A composition containing Hoveniadulcis Thunb. extract is provided to effectively treat osteroporosis and related diseases without side effects. CONSTITUTION: A pharmaceutical composition for preventing and treating bone diseases contains Hoveniadulcis Thunb. extract as an active ingredient. The bone diseases are osteroporosis, osteomalacia, racket, or metabolic bone diseases. The extract promotes bone formation by Wnt/beta-catechin signal transduction. The dose of the extract is 0.1-10 g/kg. A food composition for relieving and treating bone diseases contains Hoveniadulcis Thunb. extract as an active ingredient. [Reference numerals] (AA) Relative reporter activity(%)； (BB) Control； (CC) Hoveniadulcis Thunb. extract； (DD) HEK-TOP본 발명은 지구자 추출물을 유효성분으로 함유하는 골 질환 예방 및 치료용 조성물에 관한 것이다. 본 발명에 의한 지구자 추출물은 천연물로서 부작용이 없고, 뼈의 분해 억제가 아닌 형성을 촉진하여 기존의 뼈 분해억제제의 단점을 보완하여 골다공증 및 관련 질병의 치료에 효과적이다.
