PROTÉINES F DE RSV PRÉ-FUSION ET LEUR UTILISATION

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专利权人:

THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人:

BOYINGTON, JEFFREY,GEORGIEV, IVELIN, STEFANOV,PANCERA, MARIE,SOTO, CINQUE,SRIVATSAN, SANJAY,STEWART-JONES, GUILLAUME,KWONG, PETER, D.,GRAHAM, BARNEY, S.,MCLELLAN, JASON, S.,JOYCE, MICHAEL, GORDON,KANE

申请号：

EP14775224

公开号：

EP2970398A4

申请日:

2014.03.13

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

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