The present invention relates to process for preparing solid oral pharmaceutical compositions comprising ticagrelor or salts thereof. In particular, the present invention relates to a process for preparing solid oral pharmaceutical compositions comprising ticagrelor or salts thereof and at least one pharmaceutically acceptable excipient other than water-insoluble fillers. There is also provided a method of reducing the rate of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS) by using the composition ticagrelor or salts thereof.