PROBLEM TO BE SOLVED: To solve such a problem that it is difficult to obtain high spatial resolution while an outside diameter maintains 1 mm or 1 mm or less in an existing optical fiber, and further there exists no such a multifunctional diagnostic device as enabling biofunction observation while having an ultrafine diameter.SOLUTION: A composite-type extra-fine diameter optical fiber bundle is capable of observing a visible light and a fluorescent light at the same time, and has a high spatial resolution capable of observing cells. The irradiation using a laser and an LED light source is made possible along with the fluorescent light observation at the same time. An environment-responsive sensor is equipped on a tip part. An ultrafine form is maintained by optimizing a fiber component and bundle structure, and holds multi-functions. Vital observation and function measurement are made possible by mounting a functional probe on a fiber tip. The functional probe seals a low molecular substance in nanoparticles, and bonds it to fibers.COPYRIGHT: (C)2015,JPO&INPIT【課題】現存光ファイバでは、外径1mmか1mm以下を維持しつつ高空間分解能を得ることが困難である。更に極細径を有しつつ、生体機能観察を可能にするなどの多機能性診断装置は存在しない。【解決手段】可視光蛍光同時観察が可能で、細胞観察可能な高空間分解能をもつ複合型極細径光ファイババンドル。レーザーおよびLED光源を用いた照射と蛍光同時観察が可能。先端部に環境応答性センサを搭載。ファイバ成分とバンドル構造を最適化することにより極細形態を維持し多機能を保有。ファイバ先端に機能性プローグを装着することにより生体観察、機能計測を可能にする。機能性プローブは低分子物質をナノ粒子しに封入し、それをファイバに結合する。【選択図】なし
