An inflatable artificial pneumoperitoneum bag (800) for receiving tissue (840) during laparoscopic surgery has a tissue-receiving opening at a proximal end thereof defined by a cuff (811) at the proximal opening. The cuff (811) has a closed configuration for delivery and retrieval of the bag (800) and an open configuration to receive tissue. The cuff (811) is biased into the open configuration. The bag (800) has a main body which extends from the cuff and the main body of the bag is more flexible than the cuff (811). A biasing element (815) biass the cuff (811) into the open configuration. A tether (809) is used to close the bag for retrieval. The bag (800) creates an artificial pneumoperitoneum which isolates tissue within the bag.
