A single use applicator described herein allows for simplicity while ensuring that only the necessary amount of product in each compartment is utilized when needed. The inventive drug delivery device comprises a housing with two compartments, each containing substances separated by a barrier or membrane which can be broken apart by applying pressure to the housing. One end of the applicator comprises a tapered nozzle and cap which can be twisted off when ready to use. Once the barrier or membrane is broken, the two components, liquid and powder, will mix creating the end product. After the two components have been mixed and the user is ready to apply the end product, the user will twist the cap off of the device and apply pressure to the applicator housing in order to force the substance through the nozzle and into the eye, nasal passage, ear canal or other part of the body.
