Provided herein are conjugates for inducing tolerance of a coagulation factor protein, wherein the conjugate comprises a coagulation factor protein or an antigenic fragment or variant thereof and a Siglec ligand. Pharmaceutical compositions, methods and kits comprising the conjugates are also provided.本文係提供用於誘發凝血因子蛋白之耐受性的接合物,其中該接合物係包括一凝血因子蛋白或其抗體片段或變體以及一Siglec配體。亦提供包括此等接合物之醫藥組成物、方法及套組。