Structure below: R2 N (i) or (ii) (in formula, R1 - R4 is stipulated in this bill.)The heteroaryl chemical compound of the constituent, and the effective tonnage which include heteroaryl chemical compound and the heteroaryl chemical compound of the effective tonnage which it possesses the fact that it prescribes to the patient who needs that is included, the cancer and inflammation characteristics voice, immunology state, the nervous denaturation disease, diabetes and the obesity, nervous fault, remedies the disease or a heart vascular state where it accompanies age increase, or manner in order to prevent is offered in this bill.< Choice figure > It is not以下の構造:R2 N (I)又は(II)(式中、R1 -R4は、本明細書中に規定される。)を有するヘテロアリール化合物、有効量のヘテロアリール化合物を含む組成物、並びに有効量のヘテロアリール化合物をそれを必要とする患者に投与することを含む、癌、炎症性状態、免疫学的状態、神経変性疾患、糖尿病、肥満症、神経障害、加齢に伴う疾患、又は心血管状態を、治療する又は予防するための方法を本明細書中に提供する。【選択図】 なし