Method of treating a condition, disorder or physiological state which is improved or ameliorated by the increased expression of any one or more of ELOVL4 (Elongation of Very Long Chain Fatty Acids-Like 4), UGCG (Ceramide Glucosyltransferase), IVL (Involucrin), TGMI (Transglutaminase 1), HMOX-1 (heme oxygenase (decycling) 1) and AQP3 (Aquaporin-3) genes in a subject including administering to the subject an effective amount of an Active Agent disclosed herein.本發明係關於治療個體中因ELOVL4 (極長鏈脂肪酸樣4之延伸)、UGCG (神經醯胺葡萄糖基轉移酶)、IVL (退化素)、TGMI (轉麩醯胺酸酶1)、HMOX-1 (原血紅素加氧酶(脫環) 1)及AQP3 (水通道蛋白-3)基因之任何一或多者之表現增加而改良或改善之病狀、病症或生理狀態之方法,該方法包括向該個體投與有效量之本文中所揭示之活性劑。
