Its use as a SMAC Mimetic, Pharmaceutical compositions containing them and their use as Medicines for the Prevention and / or treatment of diseases characterized by excessive or abnormal Cell Proliferation and Associated Disorders such as cancer.Claim 1: a compound characterized by the formula (1) where r u00b9 is H or alkyl c u2081 u208b u2085； R u00b2, r u00b2 u1d43 are selected independently - H or alkyl, optionally substituted with one or more c u2081 u208b u2085 - F； r u00b3 - c u2086 u208b u2081 u2080 is selected from aryl, heteroaryl - 14 5 Members, each of these groups can be replaced optionally and independently with one or moreSelected independently, r u2076； r u00b3 is selected from alkyl or cycloalkyl c u2081 u208b u2086, c u2084 u208b u2087, cicloalquenilo c u2084 u208b u2087 or Aromatic Ring System of 5 - 14 members, each of these groups can be replaced optionally and independently with one or more selected from Mo OJ r u2076 u1d43； r u2076 is selected independent of - CN, halogen, alkyl - or c u2081 u208b u2083 c u2081 u208b u2083, alkyl, - C (o) - r u00b9 u00b2,5 - 6 heteroaryl heteroaryl group members, about 5 - 6 members can be optionally substituted by alkyl or c u2081 u208b u2083； r u2076 is phenyl, phenyl can be optionally substituted with alkyl - or c u2081 u208b u2083 is selected； r u2076 u1d43 = o, - CN, c u2081 u208b u2083 Halogen, alkyl, alkyl - or - Or c u2081 u208b u2083, - C (o) - r u00b9 u00b2 heteroaryl, 5 - 6 membersMay 5 - 6 heteroaryl group members can be optionally substituted alkyl or c u2081 u208b u2083； r u2076 u1d43 is phenyl, phenyl can be optionally substituted with alkyl - or c u2081 u208b u2083； r u00b9 u00b2 is selected nh u2082 -, - NH - alkyl Aromatic c u2081 u208b u2083, not heterociclilo 5-7 members, Or - or - alkyl c u2081 u208b u2083,Such c u2081 u208b u2083 alkyl groups can be optionally replaced with a non Aromatic heterociclilo 5-7 members； r u2074 is selected from h, c u2086 u208b u2081 u2080 - aryl, heteroaryl
