The present invention provides a pharmaceutical composition or a solid preparation containing a stabilized pharmaceutically active ingredient and a stabilizing method thereof. According to the present invention, a pharmaceutical composition can be stabilized by containing a nonpeptidic pharmaceutically active ingredient having a primary or secondary amino group, an excipient and an acidic compound. In addition, asolid preparationcontaining a pharmaceutically active ingredient, titanium oxide, a plasticizer and a chain organic acid can enhance the stability of the pharmaceutically active ingredient during light irradiation.本發明係提供一種包含經安定化的醫藥活性組分之醫藥組成物或固態製劑，及其安定化之方法。依據本發明，藉由含有具有一級或二級胺基之非肽醫藥活性組分、賦形劑、及酸性化合物可安定化醫藥組成物。另外，含有醫藥活性組分、氧化鈦、塑化劑及鏈有機酸之固態製劑可增強醫藥活性組分於光照射期間之安定性。
