Various embodiments include systems and methods for gain auto-correction. Automatic gain optimization or correction may be applied in an ultrasound system, during an automatic gain mode. The automatic gain optimization or correction may comprise automatic time gain compensation (TGC) and/or lateral gain compensation (LGC) optimization or correction. The applying of the gain optimization or correction may comprise determining an optimal gain, such as based on processing input ultrasound images； determining, based on the optimal gain, settings for a plurality of user controls of the ultrasound system (e.g., slides, knobs, etc.), corresponding to the optimal gain； and providing feedback to a user of the ultrasound system, relating to (e.g., showing) the settings for the plurality of user controls that correspond to the optimal gain. The plurality of user controls may be adjustable manually and automatically. The user controls may be physical or virtual.
