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PHARMACEUTICAL COMPOSITION, INCLUDING OMEGA-3 FATTY ACID AND HYDROXY DERIVATED STATIN AND WAYS OF ITS APPLICATION
专利权人:
АМАРИН КОРПОРЕЙШН ПиЭлСи (IE)
发明人:
РОУ Джонатан (US)
申请号:
RU2012116079/15
公开号:
RU2012116079A
申请日:
2010.09.23
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A pharmaceutical composition comprising (a) a hydroxy derivative of statin or a pharmaceutically acceptable salt thereof and (b) an oil comprising omega-3 fatty acids. The pharmaceutical composition of claim 1, wherein the omega-3 fatty acid comprises ethyl acosapentaenoate. The pharmaceutical composition according to claim 1, wherein the oil comprises at least 95% by weight of ethyl eicosapentaenoate. The pharmaceutical composition according to claim 1, wherein the oil comprises at least 95% by weight of ethyl docosahexaenoic acid. The pharmaceutical composition of claim 3, wherein the oil comprises ethyl acosapentaenoate and ethyl docosahexaenoic acid. The pharmaceutical composition of claim 5, wherein the oil comprises ethyl acosapentaenoate and ethyl docosahexaenoic acid in a molar ratio of from about 1: 1 to about 1.5: 1.7. The pharmaceutical composition according to claim 1, wherein the hydroxy derivative of statin or a pharmaceutically acceptable salt thereof is selected from the hydroxy derivative of atorvastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, fluvastatin, simvastatin, lovastatin, cerivastatin and their pharmaceutically acceptable salts. The pharmaceutical composition of claim 7, wherein the hydroxy derivative of statin is selected from ortho or a pair of hydroxyatorvastatin and its pharmaceutically acceptable salts. The pharmaceutical composition of claim 8, wherein the hydroxy derivative of statin or a pharmaceutically acceptable salt thereof is selected from o-hydroxyatorvastatin, p-hydroxyatorvastatin, p-hydroxyatorvastatin disodium, o-hydroxyatorvastatin calcium, o-hydroxyatorvastatin-lactone 5, o-hydroxyatorvastatin-lactone, o calcium, o-hydroxyatorvastatin-d5 disodium, o-hydroxyatorvastatin-d5 lactone, 2-hydrox1. Фармацевтическая композиция, включающая (a) гидроксипроизводное статина или его фармацевтически приемлемой соли и (b) масло, включающее омега-3 жирные кислоты.2. Фармацевтическая композиция по п.1, где омега-3 жирная
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