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Triazolone compound prodrug
专利权人:
EISAI R&D MANAGEMENT CO.; LTD.
发明人:
CLARK, RICHARD,MATSUURA, FUMIYOSHI,SHINODA, MASANOBU,HIROTA, SHINSUKE,KIRA, KAZUNOBU,AZUMA, HIROSHI,TAKEMURA, ATSUSHI,YASUI, SO,KUSANO, KAZUTOMI,MIKAMOTO, MASAKI,OMAE, TAKAO
申请号:
ES11725827
公开号:
ES2471815T3
申请日:
2011.05.18
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 represents phenyl optionally substituted with one to three C 1 -C 6 alkyl groups, C 1 -C 6 alkoxy or C 2 -C 6 alkenyloxy; R2 represents a hydrogen atom, C1-C6 alkylcarbonyl or pyridylcarbonyl; R3 and R4 each independently represent a hydrogen atom or C1-C6 alkyl; A represents a single bond, an oxygen atom, a group represented by Formula (II): in which Ra and Rb 10 each independently represent a hydrogen atom or C1-C6 alkyl, and * 1 and * 2 want say binding to carbonyl and R5, respectively, in Formula (I), or a group represented by Formula (III): in which Rc, Rd, Re and Rf each independently represent a hydrogen atom or C1- alkyl C6, and * 1 and * 2 have the same meanings as described above; and R5 represents C1-C6 alkyl or C3-C8 cycloalkyl, and C1-C6 alkyl or C3-C8 cycloalkyl in R5 is optionally substituted with one to three identical or different substituents selected from the group of substituents consisting of an atom of halogen, C1-C6 alkyl and C1-C6 alkoxy.Un compuesto representado por la siguiente Fórmula (I) o una sal farmacéuticamente aceptable del mismo: en la que R1 representa fenilo opcionalmente sustituido con uno a tres grupos alquilo de C1-C6, alcoxi de C1-C6 o alqueniloxi de C2-C6; R2 representa un átomo de hidrógeno, alquilo de C1-C6-carbonilo o piridilcarbonilo; R3 y R4 representan cada uno independientemente un átomo de hidrógeno o alquilo de C1-C6; A representa un enlace sencillo, un átomo de oxígeno, un grupo representado por la Fórmula (II): en la que Ra y Rb 10 representan cada uno independientemente un átomo de hidrógeno o alquilo de C1-C6, y *1 y *2 quieren decir enlazamiento a carbonilo y a R5, respectivamente, en la Fórmula (I), o un grupo representado por la Fórmula (III): en la que Rc, Rd, Re y Rf representan cada uno independientemente un átomo de hidrógeno o alquilo de C1-C6, y *1 y *2 tienen los mismos significados como se des
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