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SUBSTITUTED N-ARYLETHYL-2-AMINOQUINOLINE-4-CARBOXAMIDES AND USE THEREOF
专利权人:
BAYER AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
DR. NAGEL, JENS,DR. DRBNER, KAROLINE,DR. MLLER, JRG,DR. HAUFF, PETER,DR. JRIEN, HANNAH,DR. MOSIG, JOHANNA,DR. BAIRLEIN, MICHAELA,DR. DIETZ, LISA,DR. VON BHLER, CLEMENS,JEREMIAS - DR. STELLFELD, TIMO,D
申请号:
ARP180100886
公开号:
AR111367A1
申请日:
2018.04.10
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
1. Requirement 1: Formula compound (1)A. AR stands for phenyl or pyridine. In this case, phenyl can be replaced equally or differently with fluorine, chlorine, C832183833134 tar and C8383833131 tar to tetraethylbenzene and pyridine to sulfur dioxide. A. Fluorine, oxygenated C83218383228a, fluorinated trifluoride, or fluorinated carbon trichloride C83218838322, or fluorinated trifluoride, or two substitutes containing phenyl or pyridine groups, if linked with adjacent revocable atoms, depending on the situation, they are united to form a whole; PO methylene dioxy-O ethyl dioxy, or where fluoro-substituted phenyl can be used up to five times;It also represents a coalition or a set of formulas: - 35; 1 - X - (CR1 8304; - AR1 83040; (b) 8342; - 352,Among them, [-35; 1] represents the binding point with carbon atoms, [-35; 2] represents the binding point with carbon atoms, and X represents a binding point [-Ch-8322-].- It's...- S(= O) 8344; - O-N (R1) -,M means 0, 1 or 2, R1 means hydrogen or methyl; R1 8304; A and R1 830404; B stands for hydrogen, fluorine or methyl independently, or R1 8304; A and R1 830404; B form a global group together with the attached carbon atoms; K stands for 1, 2, 3 or 4; and R1 Repre Repre is a global group. A. Sithalogen, C8321C83832424, substitutes fluorine for up to five times, fluorine for up to five times, sulfur (trifluoromethyl) fluoride for Metoxi to Triustius, sulfur, sulfur pentafluoride, trimethylsilicon, Etinil, cyclopapile, or cyclobutio. Of these substances, fluorine and cyclohexane can be substituted for up to four times. Fluorine, R,R3_and R83088 independently represent hydrogen, halogen or methyl until fluorine trifluoride; R83099A represents halogen, C83218A tar 833183248324834; fluoride, formic acid to fluoride, hydrogen XI, methylene sulfonyl (trifluoride) fluoride, cyanide; E. Etenel, cyclopropile or cyclobutio, where fluorine can be used to replace cycloalrylonitrile and cyclotoluene up to four times; R8310 denotes - Nr 2
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