Kyowa Hakko Kirin Co., Ltd.;Kyushu University National University Corporation
发明人:
申请号：
EP11792564.4
公开号：
EP2581113A1
申请日:
2011.06.10
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention provides an anti-human TIM-3 antibody which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure thereof and exhibits higher effector activity such as an antibody-dependent cellular cytotoxicity (ADCC activity) for diseases relating to a human TIM-3 expressing cell. The present invention provides a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity； a hybridoma which produces the antibody； a DNA encoding the antibody； a vector comprising the DNA； a transformant which is obtainable by introducing the vector； a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant； a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient. In addition, the present invention provides an anti-human TIM-3 antibody having high ADCC activity by screening an anti-human TIM-3 antibody which competes with the monoclonal antibody or the antibody fragment thereof.
