A compact integrated patch may be used to collect physiological data. The patch may be wireless. The patch may comprise a plurality of sensors, each sensor configured to collect different health related data from a subject to which the patch is attached, and a communication interface configured to wirelessly and directly communicate with a mobile device, wherein the mobile device is capable of running a plurality of applications, wherein each application of said plurality is configured to utilize data from different subsets of sensors from the plurality of sensors, to provide different monitoring activities for the subject. The patch may be utilized in everyday life as well as in clinical environments.