The disclosure relates to a method of enhancing blood coagulation in a subject, comprising orally administering to the subject a procoagulant amount of a non-anticoagulant sulphated polysaccharide (NASP) in combination with a gastrointestinal epithelial barrier permeation enhancer comprising chitosan and bromelain in a manner sufficient to enhance blood coagulation in the subject. The NASP may be a naturally occurring NASP selected from the group consisting of N-acetyl-heparin (NAH), N-acetyl-de-O-sulfated-heparin (NA-de-o-SH), de-N-sulfated-heparin (De-NSH), de-N-sulfated-acetylated-he-parin (De-NSAH), periodate-oxidized heparin (POH), chemically sulfated laminarin (CSL), chemically sulfated alginic acid (CSAA), chemically sulfated pectin (CSP), dextran sulfate (DXS), heparin-derived oligosaccharides (HDO), pentosan polysulfate (PPS) or fucoidans. The NASP may also be a synthetic NASP selected from the group consisting of sulfated oligomers, sulfated pentoses, sulfated hexoses or sulfated cyclodextrins. The gastrointestinal epithelial barrier permeation enhancer may be a tight junction modulator selected from the group consisting of proteases, bile acids, polysaccharides, fatty acids and salts thereof. The disclosure also relates to a composition comprising the NASP and gastrointestinal epithelial barrier permeation enhancer.
