Constance L. Cepko,Bo Chen,Wenjun Xiong,Vedangi Sample
申请号：
US15022301
公开号：
US20160235826A1
申请日:
2014.09.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is based, at least in part, on the discovery that fragments of the histone deacetylase 4 (HDAC4) gene lacking the enzymatic domain promoted rod survival when electroporated into the retinas of a relevant mouse model of retinitis pigmentosa. Specifically, it has been discovered that only a small portion of the N-terminus of HDAC4 promotes survival of rod cells in rd1 mice. Accordingly, the present invention provides histone deacetylase 4 compositions and methods of use thereof for inhibiting neuronal cell death, e.g., retinal cell death.
