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NANOVACCIN ACTIVANT STING POUR L'IMMUNOTHERAPIE
专利权人:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
GAO, JINMING,CHEN, ZHIJIAN,LUO, MIN,WANG, ZHAOHUI,WANG, HUA,CAI, HAOCHENG,HUANG, GANG,FU, YANG-XIN
申请号:
CA3016457
公开号:
CA3016457A1
申请日:
2017.03.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer has a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.
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