Gregory A. CAPUTO,Yaquan SUN,Lei YU,Sireesh APPAJOSYULA
申请号：
US13494953
公开号：
US20130084312A1
申请日:
2012.06.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Biocompatible polymeric nanoparticles for delivery of bioactive agents, and methods for preparing the particles, are described. Polyoxalate nanoparticles of the subject technology show desired particle sizes suitable for use in drug delivery and a substantially uniform or narrow particle size distribution. The polyoxalate nanoparticles can contain water-soluble, poorly water-soluble, or water-insoluble drugs. The nanoparticles are nontoxic and are generally safe for use in humans. After being administered into the body, the nanoparticles with a high content of a bioactive agent entrapped therein can safely deliver the agent to target sites and stably release the drug at a controlled rate.
