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LOCAL ANESTHETIC ANALGESIC SUSTAINED-RELEASE DRUG DELIVERY SYSTEM, PREPARATION METHOD AND APPLICATION THEREOF
专利权人:
Xi'an Libang Biomedical Technology Co.;Ltd.
发明人:
Yufan Ma,Tao Chen,Danfeng Kong
申请号:
US16106414
公开号:
US20190314281A1
申请日:
2018.08.21
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention discloses a novel local anesthetic analgesic sustained-release drug delivery system. The system includes an internal aqueous phase, an external aqueous phase, an oil phase, an organic solvent, an isoosmotic regulator and a pH regulator. The internal aqueous phase includes an analgesic, a drug solvent and a drug solubilizer. The analgesic is selected from one of bupivacaine, levobupivacaine, ropivacaine, lidocaine and tetracaine, and the analgesic is in a free base form or an acid saline form; the drug solvent is selected from inorganic acid containing N or P; and the drug solubilizer is selected from one or more of saccharide and ring-shaped organic acid. The multivesicular liposome prepared in the present invention has the advantages of high encapsulation percentage and drug loading capacity, uniform grain size, and good sustained-release effect.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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