BEHAN, DOMINIC P.,贝汉 多米尼克P,貝漢 多米尼克P,GLICKLICH, ALAN,葛利克利奇 艾伦,葛利克利奇 艾倫,GROTTICK, ANDREW J.,葛洛堤克 安德鲁J,葛洛堤克 安德魯J,KAM, MARIA MATILDE SANCHEZ,坎姆 玛丽亚 玛蒂达 桑雪,坎姆 瑪麗亞 瑪蒂達 桑雪,SHANAHAN, WILLIAM R.,夏纳汉 威廉R,夏納漢 威廉
申请号：
TW104135662
公开号：
TW201618787A
申请日:
2015.10.29
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Provided are compositions comprising (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate, or hydrate thereof, optionally in combination with a supplemental agent, and methods for reducing the frequency of smoking tobacco in an individual attempting to reduce frequency of smoking tobacco aiding in the cessation or lessening of use of a tobacco product in an individual attempting to cease or lessen use of a tobacco product aiding in smoking cessation and preventing associated weight gain controlling weight gain associated with smoking cessation by an individual attempting to cease smoking tobacco reducing weight gain associated with smoking cessation by an individual attempting to cease smoking tobacco treating nicotine dependency, addiction and/or withdrawal in an individual attempting to treat nicotine dependency, addiction and/or withdrawal or reducing the likelihood of relapse use of nicotine by an individual attempting to cease nicotine use comprising administering (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate, or hydrate thereof, optionally in combination with a supplemental agent.本發明提供組合物,其包含視情況與補充劑組合之(R)-8-氯-1-甲基-2,3,4,5-四氫-1H-3-苯并氮呯或其醫藥上可接受之鹽、溶劑合物或水合物;及用於以下之方法:降低嘗試降低吸煙頻率之個體之該吸煙頻率;幫助嘗試終止或減少煙草產品使用之個體終止或減少煙草產品之使用;幫助戒煙並預防相關體重增加;控制嘗試戒煙之個體隨著戒煙相關之體重增加;減少嘗試戒煙之個體隨著戒煙相關之體重增加;治療嘗試治療尼古丁依賴性、成癮及/或戒斷之個體之尼古丁依賴性、成癮及/或戒斷;或降低嘗試終止尼古丁使用之個體重新再使用尼古丁之可能性,該等方法包含視情況與補充劑組合投與之(R)-8-氯-1-甲基-2,3,4,5-四氫-1H-3-苯并氮呯或其醫藥上可接受之鹽、溶劑合物或水合物。
