A device for the analysis of an endocardiac signal of acceleration. The device preprocesses the acquired endocardiac acceleration (EA) signal by cutting the signal EA collected into sub-signals EA, each one have a duration of one cardiac cycle separating the cut signals to isolate in each sub-signal EA at least one component EAx, associated with a major cardiac sound, and preferably into components EA1 and EA2 associated with the two major cardiac sounds S1 and S2 and performing a correlation on each component EA1 and EA2, to readjust each sub-signal in relation to a maximum of correlation, so as to deliver a readjusted component EA1 and a readjusted component EA2. The device further determines, starting from the isolated correlated components EA1 and EA2, a component average EA1 and a component average EA2, and to combine these components EA1 and average EA2 so as to produce an average global signal EA for one cycle. The device extracts from these information temporal markers of characteristic moments in the cardiac cycle, in particular markers of the moment of opening and closing of the aortic valve.
