ANTAGONISTES A PETITES MOLECULES DE LA MODIFICATION LIEE AU SUMO DE CRMP2 ET LEURS UTILISATIONS

• 收藏
• 分享

专利权人:

ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人:

KHANNA, MAY,KHANNA, RAJESH,GOKHALE, VIJAY,CHAWLA, REENA

申请号：

CA3052195

公开号：

CA3052195A1

申请日:

2018.02.02

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperidinyl-benzoimidazole structure which function as antagonists of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2), and their use as therapeutics for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and/or pain (e.g., neuropathic pain).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/