isolated purified extract from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, preparation thereof, and composition comprising the same as an active ingredient to prevent or treat inflammation, allergy and asthma
abstract purified extract isolated from pseudolysimachion rotundum var. A subintegrum containing an abundant amount of active ingredient, its preparation, and a composition comprising it as an active principle to prevent or treat inflammation, allergy, and asthma, refers to the new inventive industrialized methods for the preparation. Of purified industrialized extracts containing more abundant active ingredients, such as catalpol derivatives of pseudolysimachion rotundum var subintegrum extract than prepared by the conventional method of preparation disclosed in the prior art and therapeutic or functional health foods comprising the purified extract to treat and prevent inflammatory, allergic or asthmatic disease. the purified extract showed more potent anti-inflammatory, anti-allergic and anti-asthmatic activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as the inhibition test. on eosinophil reproduction, release of inflammatory immunoglobulins and chemokines in plasma and bronchoalveolar fluid, as well as suppression of airway hyperreactivity and goblet cell hyperplasia in a murine model sensitized / challenged by roe. 1/1resumo extrato purificado isolado de pseudolysimachion rotundum var. subintegrum contendo quantidade abundante de princêpio ativo, prepara‚ìo do mesmo, e composi‚ìo compreendendo o mesmo como um princêpio ativo para prevenir ou tratar a inflama‚ìo, alergia e asma, refere-se aos novos mžtodos inventivos industrializados para a prepara�‹o de extratos purificados industrializados contendo princ’pios ativos mais abundantes, como derivados catalpol de extrato de pseudolysimachion rotundum var subintegrum do que o preparado pelo mžtodo convencional de prepara�‹o revelado na tžcnica anterior e os alimentos de saœde terap�uticos ou funcionais compreendendo o extrato purificado para tratar e prevenir doen�a inflamat—ria, alžrgica ou asm‡tica. o extrato purificado mostrou ativida
