DEBS, Robert James,HEATH, Timothy D.,HANDUMRONGKUL, Chakkrapong
申请号：
EP16847422
公开号：
EP3349730A1
申请日:
2016.09.16
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides compositions, systems, kits, and methods for generating expression of one or more proteins and/or biologically active nucleic acid molecules in a subject (e.g., at therapeutic levels for extended periods required to produce therapeutic effects). In certain embodiments, systems and kits are provided that comprise a first composition comprising a first amount of polycationic structures, and a second composition comprising a therapeutically effective amount of expression vectors (e.g., non-viral expression vectors not associated with liposomes) that are CpG-free or CpG-reduced, where the expression vectors comprise a first nucleic acid sequence encoding: i) a first therapeutic protein or proteins, and/or ii) a first biologically active nucleic acid molecule or molecules.
