A topically admimstrable vasodilator formulation comprises arginine and/or one or more derivatives thereof black pepper extract and/or one or more components or derivatives thereof and peppermint extract and/or one or more components or derivatives thereof. The formulation may further comprise rosemary oil a penetration enhancers an ecdysteroid and/or one or more other agents that enhance the vasodilator activity of the formulation. The valodilalor formulation may be suitable for treating or preventing a disease disorder or condition associated with a decrease and/or impairment of blood flow in a subject by topically administration to the subject.
