IRINA YURGELONIS,KRISTEN ELISSA SYVERTSEN,MARK WILLIAM CUTLER,NARENDER KUMAR KAYLAN,ROGER MICHAEL HENDRY,YURGELONIS IRINA,SYVERTSEN KRISTEN ELISSA,CUTLER MARK WILLIAM,KAYLAN NARENDER KUMAR,HENDRY ROGER MICHAEL,ROGER MICHA
申请号：
BRPI0821558
公开号：
BRPI0821558A2
申请日:
2008.12.18
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to methods for generating genetically modified and attenuated strains of vesicular stomatitis virus (VSV) for use in the preparation of immunogenic compositions. More particularly, the invention relates to the identification of particular genetic modifications of attenuated VSV that result in an increased yield of virus and an increase in stability of the attenuated strains for preparation of the immunogenic compositions. Methods for cell culture propagation and use in large scale production of VSV is also disclosed.
