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COMPOSITIONS FOR BREAKING BIOFILMS
专利权人:
ИНК. (US);МАКНЕЙЛ-ППС
发明人:
МОРДАС Кэролин Дж. (US),ГАМБОДЖИ Роберт Дж. (US)
申请号:
RU2012126070/15
公开号:
RU2012126070A
申请日:
2010.11.18
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A composition for destroying biofilms, comprising: i. from about 0.005% to about 10% of a biofilm disruption agent containing at least one unsaturated aliphatic long chain alcohol or aldehyde of the formula: R (CR H) R (CR H) RCHR where R and R are independently H, HO, O = CH-, CH- or CH = CH-, (OCH-) R, (-OCHCH-) R, (-OCHCH (CH) -) R; R and R, independently of themselves and from each other, are HO—, O = CH—, C-C alkyl or alkene with a branched or unbranched carbon chain, —CHOH, —CHCHOH; R independently is a single bond or —O—; R independently is a single bond, —O—, (—OCH—), (—OCHCH—), (OCHCH (CH) -); R independently, represents H-, HO-, O = CH-, CH- or CH = CH-; n is an integer from 1 to 10; m is an integer from 0 to n / 2 if n is even, or (n-1) / 2 if n is odd; x is an integer from 0 to 10; y is an integer from 0 to x / 2 if x is even, or (x-1) / 2 if x is odd, and z is an integer from 0 to 5; s is an integer ≤n; and t is an integer ≤x, provided that: if none of the groups R, R, R or R contains an unsaturated bond C = C, then m + y is at least 1; R and R are components in which R is not (-OCH-), (-OCHCH-), (OCHCH (CH) -) and R is not (OCH-) R, (-OCHCH-) R, (-OCHCH (CH) -) R; carbon length is the carbon chain from R to R, continuously or intermittently, is from 8 to 13 carbon atoms; and at least one of any R, R, R and R contains HO— or O = CH—; ii. optionally therapeutically active substance; and iii. a carrier selected from the group consisting of a non-oral carrier, a pharmaceutically acceptable carrier, a carrier acceptable for1. Композиция для разрушения биопленок, содержащая:i. от приблизительно 0,005% до приблизительно 10% средства разрушения биопленок, содержащего по меньшей мере один ненасыщенный алифатический длинноцепочечный спирт или альдегид формулы:R(CR H)R(CR H)RCHRгде Rи Rнезависимо друг от друга представляют собой H-, HO-, O=CH-, CH- или CH=CH-, (­OCH-)R, (-OCHCH-)R, (-OCHCH(CH)-)R; Rи Rнезависимо от себя самих и друг от друга представляют собой
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