The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral particles as well as methods of using the same are also provided.本發明提供包含PDGF及VEGF結合部分之融合蛋白及編碼該等融合蛋白之重組病毒粒子。亦提供包含該等融合蛋白及病毒粒子之組合物以及其使用方法。