The invention discloses a pressure sensor and a blood pressure measurement device with the pressure sensor. The pressure sensor includes a case and a pressure sensing element. The both opposite sides of the case have a concave portion and a convex portion, respectively. A recessed space is formed in the concave portion. The pressure sensing element is disposed at the case and configured to be pressed by the convex portion to deform toward the recessed space. The pressure sensor of the present invention may have a higher sensing sensibility.本發明揭露一種壓力感測器及具有該壓力感測器的血壓量測裝置。壓力感測器包括一殼體以及一壓力感測元件。殼體的二相對側分別具有一凹部與一凸部,其中一凹陷空間形成在凹部。壓力感測元件設置於殼體,且配置來受凸部擠壓而朝凹陷空間形變。本發明的壓力感測器可具有較高的感測靈敏度。2‧‧‧壓力感測器21‧‧‧殼體211‧‧‧凹部212‧‧‧凸部213‧‧‧第一子殼體件214‧‧‧第二子殼體件22‧‧‧壓力感測元件F1‧‧‧外力S‧‧‧凹陷空間Z‧‧‧投影方向