Qiongyu GUO,Jordan J. GREEN,Randall A. MEYER,Corey J. BISHOP,Anand KUMAR,Gregg L. SEMENZA
申请号：
US15564461
公开号：
US20180140702A1
申请日:
2016.04.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors with or without chemotherapeutic agents for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.
