DERIVES DE CAMPTOTHECINE A ACTIVITE ANTITUMORALE

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专利权人:

INDENA S.P.A.

发明人:

FONTANA, GABRIELE,BOMBARDELLI, EZIO,MANZOTTI, CARLA,BATTAGLIA, ARTURO,SAMORI, CRISTIAN

申请号：

CA2658900

公开号：

CA2658900C

申请日:

2007.07.13

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention is directed to 5-substituted thio-camptothecinderivatives of the formula (l)(see formula I)wherein:R is hydrogen or -N3；R1 is hydrogen, ethyl or the group ¨CH=N-O-C(CH3)3；R2 is hydrogen or ¨CH2N(CH3)2；R3 is hydrogen or the group (see formula II) ； andpharmaceutically acceptable salts, isomers, enantiomers, diastereomersthereof and mixtures thereof having antitumor activity, the processes for thepreparation thereof, the use thereof as antitumor drugs and pharmaceuticalcompositions containing them.

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