A uric acid-lowering agent containing, as an active ingredient, a tyrosine-containingcyclic dipeptide selected from the group consisting ofcyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine,cyclotyrosylglycine, cyclotyrosyltyrosine, cyclophenylalanyltyrosine,cycloleucyltyrosine, cyclolysyltyrosine, cyclohistidyltyrosine,cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine,cycloisoleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine,cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine,cyclomethionyltyrosine, and cyclotyrosylcysteine, or a salt thereof. The uricacid-lowering agent of the present invention has an excellent action oflowering auric acid level, and the uric acid-lowering agent is useful in, for example,prevention or treatment of hyperuricemia, gout or the like.
