The invention provides asensor device comprising a substrate, especially a needle with a needle tip, wherein the substrate, especially the needle, even more especially the needle tip, comprises a sensor unit, wherein the sensor unit includes a stacked layer structure including an electrode layer, wherein the stacked layer structure further includes a nanogap dividing the electrode layer in a first electrode and a second electrode with the nanogap in between, wherein the nanogap has a width (w) selected from the range of 10-500 nm, such as from the range of 20-200 nm, and wherein in a specific embodiment the needle further comprises a microfluidic channel structure with an orifice, wherein the orifice is especially arranged at the needle tip, for delivery or extraction of a fluid.
