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CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE
- 专利权人:
- 发明人:
- 申请号：
- HK17107852.3
- 公开号：
- HK1233963A
- 申请日:
- 2017.08.08
- 申请国别(地区):
- HK
- 年份:
- 2018
- 代理人:
- 摘要：
- It also provides a pharmaceutically acceptable Composition and Methods of use of the compounds for preparing medicines that modulate Skeletal Muscle contractility.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt thereof, wherein R1 is selected from Hydrogen, halogen, alkyl of C1 CN, - 6, - 6 haloalquilo C1, C (o) C (o) nrbrc prays, prays, nrbrc, aryl and heteroaryl of C6 - 10 5 - 10 members R2 is selected between cycloalkyl C 3 - 8 - 8 heterocicloalquilo cicloalquenilo C3, 3 - 8 members, heterocicloalquenilo 3 - 8 members,C6 10 aryl, heteroaryl 5-10 members and nrbrc, where each group C3 C3 cicloalquenilo cycloalkyl - 8 - 8 - 8 heterocicloalquilo 3 members, heterocicloalquenilo 3 - 8 members, aryl and heteroaryl c6-10 5-10 members is optionally substituted with 1, 2, 3 4 or 5 Substituent S selected from Halogen, CN, Oxo, (CH2) - (CH2) (or NOC) RA (CH2) (or NOC) ora, (CH2) (or NOC) nrbrc,Nnrbrc (CH2), (CH2) nnrdc (or RA), (CH2) nnrdc (ORA), (CH2) nnrdc (OR) nrbrc, (CH2) nnrdc (o) C (o) nrbrc, (CH2) nnrdc (S) RA (CH2) nnrdc (ORA, (S) CH2) nnrdc (S) nrbrc, (CH2) nnrdc (NRE) nrbrc, (CH2) nnrds (or RA), (CH2) nnrdso2ra, (CH2) nnrdso2nrbrc, (CH2) NC (or RA), (CH2) NC (OR) ora, (CH2) (or nrbrc (NC) CH2) nc (S) RA (CH2) NC (S) (ORA, CH 2) NC (S) nrbrc, (CH2) NC (NRE) nrbrc, (CH2) nsra, (CH2) hl (or RA), (CH2) nso2ra, (CH2) nso2nrbrc, alkyl C1 - 6Haloalquilo C1 - C2 - alquenilo 6, 6, 6 alquinilo C2, C3 - (CH2) ncicloalquilo nheterocicloaiquiio 8, (CH2) 3 - 8 members, narilo C6 - (CH2) 10 and (CH2) nheteroarilo 5-10 members, where each of the 6 alquenilo alkyl groups C1, C2 alquinilo - 6 - 6, C2, C3 ncicloalquilo - (CH2) 8, (CH2) nheterocicloaiquilo d And 3 - 8 members,Narilo C6 - (CH2) 10 and (CH2) nheteroarilo 5-10 members is optionally substituted with 1, 2, 3, 4 or 5 substituents selected from RF R3 is Hydrogen, halogen, alkyl of C1 CN, - 6, - 6 haloalquilo C1, C (o) C (o) nrbrc ora nrbrc, ora, c6-10, aryl and heteroaryl 5-10 members R4 is selected
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
