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異種間特異的PSMA×CD3二重特異性単鎖抗体
专利权人:
アムゲン リサーチ (ミュンヘン) ゲーエムベーハー
发明人:
クファー,ペーター,ラウム,トビアス,キッシェル,ロマン,ルッターブゼ,ラルフ,ホフマン,パトリック,ラウ,ドリス,マンゴールド,スザンネ,クリンガー,マティアス,シャーラー,イブリン,ハウスマン,スザンネ,フルール,ペトラ,シュタイガー,カローラ
申请号:
JP20110529563
公开号:
JP6126782(B2)
申请日:
2009.10.01
申请国别(地区):
日本
年份:
2017
代理人:
摘要:
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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