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תרופות חלבון לטיפול בתאים מזדקנים
专利权人:
BIOATLA LLC
发明人:
申请号:
IL26762319
公开号:
IL267623D0
申请日:
2019.06.25
申请国别(地区):
IL
年份:
2019
代理人:
摘要:
Methods of generating conditionally active proteins that target senescent cells and which are conditionally active in an extracellular environment of a senescent cell. The methods include discovery methods using libraries of evolved proteins and assays employing physiological concentrations of components of bodily fluids. Also disclosed are conditionally active proteins for killing or removing senescent cells, pharmaceutical compositions employing these conditionally active proteins and methods for treatment of age-related diseases, conditions or disorders using same. The conditionally active proteins may be further evolved, conjugated to other molecules, masked, reduced in activity by attaching a cleavable moiety.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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