Steven John Durrant;Philip Michael Reaper;Ronald Marcellus Alphonsus Knegtel;Jean-Damien Charrier
发明人:
Jean-Damien Charrier,Steven John Durrant,Ronald Marcellus Alphonsus Knegtel,Philip Michael Reaper
申请号：
US13106178
公开号：
US20120177748A1
申请日:
2011.05.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention； methods of treating various diseases, disorders, and conditions using the compounds of this invention； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena； the study of intracellular signal transduction pathways mediated by such kinases； and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula III:wherein the variables are as defined herein.
