Old, Llyod J.,Johns, Terrance Grant,Stockert, Elizabeth,Scott, Andrew Mark
申请号：
AU2008287335
公开号：
AU2008287335B2
申请日:
2008.08.14
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to antibodies, particularly antibody 175, andfragments thereof or antibodies derived therefrom, which bind to the EGF receptor,particularly to amplified or overexpressed epidermal growth factor receptor(EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are usefulin the diagnosis and treatment of cancer. Recombinant or hybrid antibodies havingthe variable region heavy or light chain sequence(s) of antibody 175 are alsoprovided. The antibodies of the present invention may also be used in therapyin combination with chemotherapeutics or anti-cancer agents and/or with otherantibodies or fragments thereof.
