PICKER, LOUIS,HANSEN, SCOTT,FRUEH, KLAUS,MALOULI, DANIEL
申请号：
EP14759837
公开号：
EP2964769A4
申请日:
2014.03.05
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein (or an ortholog thereof) are provided. CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL130 protein (or an ortholog thereof) but lacking an active UL128 protein are also provided. In addition, methods of using CMV vectors to generate an immune response characterized as having at least 10% of the CD8+ T cells directed against epitopes presented by MHC Class II are provided.
