A microwave ablation system configured for use in luminal network, comprising: a microwave energy source (16); a tool (14) for treating tissue, the tool configured to receive microwave energy from the microwave energy source; an extended working channel (190) configured to provide passage for the tool; a locatable guide catheter (12) including a position sensor (96) positionable through the extended working channel and configured to navigate the extended working channel adjacent the target tissue (68) ; and at least one imaging modality for confirming placement of the tool within target tissue.