The invention relates to a temperature regulation system for regulating the temperature of a portion of a body, in particular of a user's body. The system comprises at least one temperature sensor 1004a, 1004b, 1004c adapted to generate a temperature measurement that relates to a temperature of a given portion of a body, at least one temperature adjustment element 1006a, 1006b, 1006c adapted to provide heat and/or cold to a given portion of the body, arranged on or in the flexible support, a memory unit 1016, 1024 adapted to store at least one threshold temperature related value, a controlling unit 1022, 1024, 1032, 1034 in communication with the temperature sensor, with the memory unit 1016, 1024 and with the temperature adjustment element. The controlling unit is configured to receive the instant temperature of a given portion of the body from the temperature sensor, perform a comparison between at least one instant temperature related value and a triggering temperature related value, activate the temperature adjustment element to provide heat or cold to a given portion of the body depending on the result of said comparison. The memory unit is further adapted to store at least one user profile information related to a user profile parameter, and the controlling unit is further configured to determine the triggering temperature related value based on said threshold temperature related value, said user profile information and at least one user activity information related to a user instant activity parameter.L'invention concerne un système de régulation de température pour réguler la température d'une partie d'un corps, en particulier du corps d'un utilisateur. Le système comprend au moins un capteur de température 1004a, 1004b, 1004c conçu pour générer une mesure de température qui se rapporte à une température d'une partie donnée d'un corps, au moins un élément de réglage de température 1006a, 1006b, 1006c conçu pour fournir de la chaleur et/ou du froid à une part
