596503 Disclosed herein are adjuvant and immunogenic compositions comprising a TLR-4 agonist and a saponin in a liposomal formulation, and a non-ionic isotonicity agent are provided, wherein the concentration of sodium chloride or ionic strength is less than 100mM. Additionally disclosed herein is a process for preparing said immunogenic compositions comprising the step of reconstituting a lyophilised composition comprising at least one antigen or antigenic preparation with an aqueous adjuvant composition.
