A syringe assembly includes a tubular barrel having an open proximal end, a distal end, and an internal a fluid retaining chamber. A plunger is slidingly received in the chamber and is configured to draw fluid into and expel fluid from the chamber. A hollow projection extends from the distal end of the barrel and a cannula extends from the hollow projection. The cannula may have a spiked tip, a transverse orifice, and longitudinally disposed bi-lateral fluid flow channels. The cannula is adapted to penetrate the seal of a medical access point, such as a medicine vial, IV port, or catheter port. A receiving collar including one or more male threads surrounds the hollow projection and the cannula and is adapted to releasably engage a needle hub. The needle hub has an internal cavity configured to matingly receive and cover the cannula.
