Provided are an α-amino acrylate microbicide, and a preparation method therefor and uses thereof. Based on the principle of pesticide molecular design, the structural reform of the agricultural anti-plant virus activity is carried on lead compounds having the medical anti-coronavirus activity, and a series of α-amino-acrylic derivatives are designed and synthesized, and in particular, α-amino acrylic derivatives containing piperidine rings are synthesized, and the systematic biological activity screening is carried by using known compounds as positive control compounds, which provides many effective anti-virus leading molecules for the preparation of pesticides, and has positive significance to the reduced use of f pesticides and the protection of environmental ecology.