Southwest Research Institute;Northwestern University
发明人:
XingGou Cheng,Thomas A. Mustoe,Robert D. Galiano,Seok Jong Hong,Ping Xie,Shengxian Jia
申请号：
US15949000
公开号：
US10716758B2
申请日:
2018.04.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.
