In the conventional caries prevention methods using antibacterial agents, enzyme inhibitors or antibiotics, extracellular polysaccharides of oral biofilms inhibit the penetration of the antibacterial agents, enzyme inhibitors, antibiotics or the like and, therefore, desired anticarious effects can be hardly achieved. In addition, it is not preferred to use such antibacterial agents and the like because of the high risk of inducing the appearance of resistant bacteria. Accordingly, it has been required to develop a more safe and more effective method for preventing caries not by controlling caries causing bacteria but by preventing biofilm formation by the caries causing bacteria. The present invention enables the prevention of biofilm formation leading to dental caries by using a composition which regulates quorum sensing.傳統上使用某種抗菌劑、酵素抑制劑或抗生物之齲齒抑制法，因為口腔生物被膜之菌體外多糖阻礙抗菌劑、酵素抑制劑、抗生素等之滲透，難以顯示目標之抑制齲齒的效果。並且，因為使用抗菌劑等，出現抗藥耐性菌的危險性高，所以並不適宜。因此，期望有並非進行控制齲齒原因菌，而是開發藉由進行控制由齲齒原因菌形成的生物被膜，而更安全且效果高之齲齒抑制方法。本發明係藉由控制聚量感應(quorum sensing)之組成物而可抑制齲齒生物被膜形成。
